Badass ninja science fiction writer Charlie Stross has just posted a killer essay on the futility of space explorationcolonization. Nutshell: it's far and hostile, and we can't even figure out how to live in the Gobi desert or the ocean's floor, infinitely closer and more hospitable.
Here's a handy metaphor: let's approximate one astronomical unit – the distance between the Earth and the sun, roughly 150 million kilometres, or 600 times the distance from the Earth to the Moon – to one centimetre. Got that? 1AU = 1cm. (You may want to get hold of a ruler to follow through with this one.)
The solar system is conveniently small. Neptune, the outermost planet in our solar system, orbits the sun at a distance of almost exactly 30AU, or 30 centimetres – one foot (in imperial units). Giant Jupiter is 5.46 AU out from the sun, almost exactly two inches (in old money).
We've sent space probes to Jupiter; they take five and a half years to get there if we send them on a straight Hohmann transfer orbit, but we can get there quite a bit faster using some fancy orbital mechanics. Neptune is still a stretch – only one spacecraft, Voyager 2, has made it out there so far. Its journey time was 12 years, and it wasn't stopping. (It's now on its way out into interstellar space, having passed the heliopause some years ago.)
The Kuiper belt, domain of icy wandering dwarf planets like Pluto and Eris, extends perhaps another 30AU, before merging into the much more tenuous Hills cloud and Oort cloud, domain of loosely coupled long-period comets.
Now for the first scale shock: using our handy metaphor the Kuiper belt is perhaps a metre in diameter. The Oort cloud, in contrast, is as much as 50,000 AU in radius – its outer edge lies half a kilometre away.