The clip above is from Stay Tooned!, a 1996 computer game developed by Funnybone Interactive. From Wikipedia:
The player takes the place of an ordinary patron living in an apartment. The player starts off simply channel-surfing with a TV remote and watching short cartoons and commercials that parody real-life shows (such as Seinfeld, which is parodied as Whinefeld). One channel even has the game’s chief programmer providing hints on how to play the upcoming game. Several cartoon characters either forbid or encourage the player to push the red button on their remote as the player surfs the channels. When the player pushes the button, the cartoons break out of the television set, steal the remote, and cause the entire apartment complex to go into animated form. The player must recover the television remote, which is the only thing that can zap the escaped toons and send them back to TV Land, the fictional toon world found within the depths of the television.
(via r/ObscureMedia)