Nemo, my Great Pyr, tends to not like chewing on fake stuff. He's loved this Galileo Nylabone for years, however.
Nylabones cover the spectrum of dog-chew toughness. Puppy softchews are like plastic gel caps to my big dog, This hard bone is barely scored by his massive teeth.
The flavoring seems to last a long time, or Nemo just got used to chewing this bad boy for comfort. Sometimes I'll put a bit of peanut butter on it, if I just want him to settle down and leave me be.
Nemo is a 120lb chewing enthusiast. This bone, however, holds up.