NYMag’s Max Read considers whether or not it is a good idea to preemptively block anyone you see with an anime avatar, that having become a signifier for a particular type of angry, prolix adolescent.
…for practical purposes, if you are besieged by trolls and are also okay with blocking people who might be extremely intelligent and engaging and also fervent otaku, all you need to know is that the “anime avatar” is a mostly though not entirely reliable indicator of trolldom, and block anyone you see with one. But I would suggest you not.
See also this bit ‘o fake news from 2014: Study: Anime Avatar Makes Opinions Up To 90% Less Relevant