This is Devo and Neil Young performing Young's "Hey Hey, My My (Into the Black)." Seriously! It's from the 1982 comedy Human Highway, starring and co-directed by Bernard Shakey aka Neil Young. (Thanks, Gabe Adiv!)
Devo and Neil Young play "Hey Hey, My My (Into the Black)"
UPDATE: Sadly, "This video is no longer available due to a copyright claim by Shakey Pictures."