The video description says it all, really:
Science fiction legend and grand master Jack Vance, 96, owns you completely with his ukelele and kazoo. He plans to sell music from his Go For Broke Jazz Band as well as the e-books already for sale on his website. Vance sings and plays harmonica, kazoo, ukelele and jug, and his friend Kevin Boudreau plays string bass and the washboard. Taken during a recent interview with Vance, for Locus Magazine. The Vance interview will appear in the August 2012 issue of Locus.
(Thanks, Spontaine!)