Snip from an MTV.com interview with director (also painter, video artist, and performance artist) David Lynch:
MTV: You shot Inland Empire using digital technology. Will you ever go back to film?
Lynch: Never. Digital is so friendly for me and so important for the scenes, a way of working without so much downtime. It's impossible to go back. Film is a beautiful medium, but the world has moved on. The amount of manipulation we can do, anybody can do, is so much the future. Film is so big and heavy and slow, you just die. It's just ridiculous.
Link, via Deadline Hollywood Daily. (image: Rita Molnar, via Wikipedia)